Protein Details: KCa2.2 (Potassium intermediate/small conductance calcium-activated channel; subfamily N member 2)

Protein ID

ICDB_Pro_1118

Protein Name

KCa2.2 (Potassium intermediate/small conductance calcium-activated channel; subfamily N member 2)

Gene Name

KCNT2; SLICK

Organism

Homo sapiens (Human)

Length

1135 amino acids

AlphaFoldDB

AF-Q6UVM3-F1-model_v4.pdb

Function

Outward rectifying potassium channel. Produces rapidly activating outward rectifier K(+) currents. Activated by high intracellular sodium and chloride levels. Channel activity is inhibited by ATP and by inhalation anesthetics;such as isoflurane (By similarity). Inhibited upon stimulation of G-protein coupled receptors;such as CHRM1 and GRM1

Sequence

MVDLESEVPPLPPRYRFRDLLLGDQGWQNDDRVQVEFYMNENTFKERLKLFFIKNQRSSLRIRLFNFSLKLLSCLLYIIRVLLENPSQGNEWSHIFWVNRSLPLWGLQVSVALISLFETILLGYLSYKGNIWEQILRIPFILEIINAVPFIISIFWPSLRNLFVPVFLNCWLAKHALENMINDLHRAIQRTQSAMFNQVLILISTLLCLIFTCICGIQHLERIGKKLNLFDSLYFCIVTFSTVGFGDVTPETWSSKLFVVAMICVALVVLPIQFEQLAYLWMERQKSGGNYSRHRAQTEKHVVLCVSSLKIDLLMDFLNEFYAHPRLQDYYVVILCPTEMDVQVRRVLQIPMWSQRVIYLQGSALKDQDLLRAKMDDAEACFILSSRCEVDRTSSDHQTILRAWAVKDFAPNCPLYVQILKPENKFHIKFADHVVCEEEFKYAMLALNCICPATSTLITLLVHTSRGQEGQQSPEQWQKMYGRCSGNEVYHIVLEESTFFAEYEGKSFTYASFHAHKKFGVCLIGVRREDNKNILLNPGPRYIMNSTDICFYINITKEENSAFKNQDQQRKSNVSRSFYHGPSRLPVHSIIASMGTVAIDLQDTSCRSASGPTLSLPTEGSKEIRRPSIAPVLEVADTSSIQTCDLLSDQSEDETTPDEEMSSNLEYAKGYPPYSPYIGSSPTFCHLLHEKVPFCCLRLDKSCQHNYYEDAKAYGFKNKLIIVAAETAGNGLYNFIVPLRAYYRPKKELNPIVLLLDNPPDMHFLDAICWFPMVYYMVGSIDNLDDLLRCGVTFAANMVVVDKESTMSAEEDYMADAKTIVNVQTLFRLFSSLSIITELTHPANMRFMQFRAKDCYSLALSKLEKKERERGSNLAFMFRLPFAAGRVFSISMLDTLLYQSFVKDYMISITRLLLGLDTTPGSGFLCSMKITADDLWIRTYARLYQKLCSSTGDVPIGIYRTESQKLTTSESQISISVEEWEDTKDSKEQGHHRSNHRNSTSSDQSDHPLLRRKSMQWARRLSRKGPKHSGKTAEKITQQRLNLYRRSERQELAELVKNRMKHLGLSTVGYDEMNDHQSTLSYILINPSPDTRIELNDVVYLIRPDPLAYLPNSEPSRRNSICNVTGQDSREETQL

PDB Structures

Ligand Binding

1. DICL_CP

2. DICL_Pep

Binding Site

1025..1032

Disease

Developmental And Epileptic Encephalopathy 57 and Early Infantile Epileptic Encephalopathy

Location

DOI ID

10.1523/jneurosci.23-37-11681.2003; 10.1038/ng1285; 10.1186/1471-2164-8-399; 10.1038/nature04727; 10.1101/gr.2596504; 10.1523/jneurosci.3372-05.2006; 10.1016/j.celrep.2017.09.088; 10.1126/science.1133427

RefSeq

NP_001274748.1 [Q6UVM3-2]; NP_001274749.1 [Q6UVM3-3]; NP_940905.2 [Q6UVM3-1]